There is disagreement regarding the causes of the Tourette's Syndrome. The exact cause is not known. In recent years, it has been more widely accepted that both genes and environment are factors with Tourette's patients. However, studies have shows that vast majority of people with Tourette's inherited the disorder from their parents.
A person with Tourette's has about a fifty percent chance of passing it on to one of his or her children. However, not everyone who inherits this genetic predisposition will show symptoms of the disorder. In fact, very few children of persons with Tourette's require medical attention for the disorder. Tourette's is a disorder with variable expression. It may be shown in the form of milder tic disorders such as transient tics.
An individual's emotional health, physical health or psychosocial factors can influence the severity of Tourette's. It has also been observed that autoimmune processes can affect the onset of tics and exacerbate them in some cases. Males are also much more likely than females to suffer from the disorder.
It is believed that Tourette's results from dysfunction in the cortical and subcortical regions of the brain potentially caused by circuit failures connecting the regions. The thalamus, frontal cortex, and basal ganglia are also involved. It is also thought that some types of obsessive–compulsive disorders are genetically linked to Tourette's. However, a genetic relationship has not been established.